JIST

Abstract

Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI), used in the treatment of depression. Venlafaxine is associated with high risk of suicidal ideation and complete suicide. A 32 year old female, who was treated with venlafaxine, died following ingestion of large dose of venlafaxine and escitalopram. Cadiotoxicity and neurotoxicity following ingestion of venlafaxine is known, however post-mortem studies are very few in literature. This case highlights the toxicity of venlafaxine and escitalopram with its histopathological findings of tissue and various drug interactions.