Methaemoglobin Analysis in Acute Dapsone Poisoning

Authors

  • Vijayakumar PG
  • * Rajendiran C
  • Malathi D
  • Suganya A

Keywords:

Dapsone overdose; Methaemoglobin (MetHb); Spectrophotometry, Liver function tests

Abstract

A case of acute dapsone poisoning in a 21 year-old female is being reported. Dapsone is well known for inducing serious methaemoglobinaemia and haemolysis in overdose situations. Estimating the methaemoglobin (MetHb) concentration in the blood is critical for effective management. Quantification of MetHb by spectrophotometer is generally advocated along with complete haematological and liver function investigations.

In this paper, we highlight the importance of quantifying MetHb by spectrophotometer, which is very simple, and demonstrates high sensitivity.

Published Date

07-Jan-2012

Issue

Vol.8 Issue No.1 (2012): Journal of Indian Society of Toxicology

Section

Articles