JIST

Abstract

All the different manner in poisoning cases are more common in India than in Western countries owing to the easy availability of poisonous substances due to non-stringent application of the laws of the land. Accidental poisoning is also on an increase because of the greater use of chemicals for agro-industry and domestic purposes. Organophosphorus poisoning is the most commonly encountered agro-poison. OP compounds are widely used as insecticides in our agricultural setting. They are easily available, and no real care is taken while handling these compounds which have also been used for the purposes of suicides in developing countries. Acute tubular Necrosis has been seen in OP poisoning very rarely and only a few cases have been reported in medical literature. Furthermore, the main mechanism by which Organophosphates can cause acute tubular necrosis has been debated. Different mechanisms have been suggested that can cause acute tubular necrosis. Organophosphates might also cause oxidative stress, direct damage to the renal tubules, rhabdomyolysis, and hypovolemia due to dehydration. This is a case of organophosphorus poisoning with clear findings of the rare complication, acute tubular necrosis in the histopathology.