JIST

Abstract

Carbamates are used as insecticides, fungicides, nematocides, accaricides, molluscides very extensively. The present study is aimed to evaluate the oxidative stress markers MDA (end product of lipid peroxidation) and reduced glutathione. In the present study the effect of 1/10th LD50 of thiodicarb (a carbamate) was studied in different regions of Albino rats which were exposed to 10, 20 and 30 days respectively. The results of the present study clearly indicate that oral administration of thiodicarb caused a significant elevation in LPO and XOD in all the regions of the brain. A gradual decline in SOD, CAT, GPx and GR was noticed in experimental rats. From the results it can be concluded that the regular dosing of carbmate may lead to gradual depletion in the activities of SOD, CAT, GPx and GR, thus resulting in the production of free radicals in the rats. The present study indicates that oxidative stress of the brain is region specific. Disturbances in the antioxidant cascade in the brain regions also indicate an adaptive biochemical response to the thiodicarb induced oxidative stress