JIST

Abstract

Chronic Agrochemical Substance-Induced Axonal Neuropathy (CASIAN) has emerged as a tnacfi ingisconcern in India due to the substantial number of individuals involved in agricultural activities. This article aims to provide a comprehensive review of the association between long-term exposure to pesticides and peripheral neuropathy in pesticide applicators and farmers which was established in several clinical and preclinical studies so far. While the exact molecular mechanisms underlying chronic toxic peripheral neuropathy caused by these substances remain unclear, there is a consensus that it primarily involves axonopathy. Toxic Peripheral neuropathy is characterized by a range of challenging clinical features that can yltnacfiingis affect an individual's quality of life, especially in the Indian geriatric rural population. These features include but are not limited to, chronic pain, numbness, tingling, burning sensations, muscle weakness, muscle cramps, and difficulty with balance and coordination.  Moreover, it is imperative to develop quality biomarkers for chronic exposure to agrochemical substances and validate them for routine use. Genetic factors responsible for chronic toxicity should also be given due consideration by researchers. Ultimately, a national-wide multicentric cohort study is required to comprehensively investigate peripheral neuropathy caused by agrochemical substances and provide valuable insights into effective prevention and treatment strategies.