JIST

Abstract

Introduction :

Organophosphorus compound (OPC) poisoning is a significant global health concern, particularly in developing countries, results in high mortality rates. Conventional markers such as serum cholinesterase levels have limitations in predicting disease severity, necessitating the exploration of alternative biochemical markers like serum creatinine phosphokinase (CPK).

Aims :

To evaluate the significance of serum CPK levels as the prognostic indicator in acute OPC poisoning and assess its correlation with clinical severity using the Peradeniya OPC poisoning (POP) score.

Methodology :

A hospital-based cross-sectional study was conducted in a tertiary-care teaching hospital over 18 months, including 30 patients with confirmed OPC poisoning. Serum CPK levels were measured on day 0, 3, and 5 and correlated with POP scores and the need for mechanical ventilation. Statistical analysis was performed using SPSS. Ethics clearance was obtained.

Results :

A strong positive correlation was observed between POP scores and CPK levels (r on day 0 – 0.763, day 3 – 0.803, day 5 – 0.683; all p values <0.001), indicating increased poisoning severity is associated with elevated CPK levels. Additionally, a significant negative correlation was found between the mechanical ventilation and both POP scores (r -1.000 on day 5) and CPK levels (r -0.683, p <0.001).

Conclusion :

Serum CPK serves as a valuable prognostic marker in OPC poisoning, correlating with disease severity and the need for mechanical ventilation. The integration of CPK monitoring with POP scoring can enhance early risk stratification and guide clinical decision-making for better patient outcomes.