JIST

Abstract

Background : Organophosphorus compounds (OPC) are widely used as pesticides and are a leading cause of poisoning in rural India. This study aimed to identify clinical and biochemical parameters inuencing prognosis and duration of hospital stay in OPC poisoning cases.

Materials and Methods: A cross-sectional study was conducted over one year on patients with acute OPC poisoning admitted to the emergency ward and ICU of a tertiary hospital in Bundelkhand. Demographic, clinical, and laboratory parameters were collected retrospectively. Severity was assessed using the Peradeniya Organophosphorus Poisoning (POP) scale. Statistical analysis was performed using SPSS 26.0.

Results: Of 106 patients, 97 met inclusion criteria. Mean age was 34.2 ± 11.4 years; 59.8% were male. Mean ingestion-to-presentation interval was 3.8 ± 2.7 hours, and mean POP score was 2.8 ± 1.9. Longer hospital stay was significantly associated with low pH (p = 0.014), high lactate (p = 0.020), elevated serum sodium (p = 0.004), higher POP score (p = 0.002), and need for invasive ventilation (p = 0.005). Mortality occurred in 11 patients (11.3%) and was significantly linked to low pH (p = 0.039), hypokalemia (p = 0.015), elevated total leukocyte count (p = 0.021), raised SGOT (p = 0.016), SGPT (p = 0.012), and blood urea (p = 0.001). Blood urea had the strongest predictive value for mortality (AUROC 0.811).