JIST

Abstract

Background: In Asia around 50% poisoning are due to organophosphorus (OP) poisoning. The estimated mortality from Organophosphates ingestion ranges from 10% to 20%. Objective: The present study was undertaken to study the glycemic changes in acute organophosphorus (anticholinesterase) poisoning and its relationship with severity, morbidity and mortality.

Methods: This prospective observational study was conducted in Government Medical College, Srinagar; Jammu Kashmir; India. Two hundred six patients with organophosphorus poisoning were studied. 

Results: In this study, the mortality was 10.2% (21 deaths in 206 patients), and ventilation was required in 29 (14.07%) patients. In patients who expired, glycosuria was found in 76.2% and blood glucose levels were 216±61 mg/dl, as compared to patients who survived in whom glycosuria was found in 9.2% and blood glucose levels were 136±88 mg/dl(P <0.005). Conclusion: Glycemic changes (hyperglycemia and glycosuria) are good markers for predicting morbidity and also assessing need for ventilator support.