JIST

Abstract

Introduction: Although studies are available on hepato-renal toxicity, lipid peroxidation products and the antioxidant status in experimental animals, a detailed report on exposed individuals is meagre. We aimed to study the variation in oxidative stress markers and correlate with hepato-renal parameters among exposures.

Method: Oxidative stress status and hepato-renal activity were studied in blood samples obtained from 50 individuals who were exposed to diesel combustion nanoparticles with a minimum work history of 8 year in the age range of 32–60years. Controls were age-matched university students and people living in hilly and forest areas. They were evaluated for oxidative stress markers, including superoxide dismutase, catalase, lipid peroxidation in blood and hepato-renal activity parameters like serum levels of bilirubin, SGOT, SGPT, urea and creatinine.

Results: The results show increased oxidative stress markers and variation among the hepato-renal parameters. It is concluded that exposures to diesel combustion nanoparticles are exposed to more oxidative stress and associated with a significant stress on hepatic and renal tissues.

Conclusion: The measurement of serum levels of bilirubin, SGOT, SGPT, urea and creatinine among chronic exposures and correlating with oxidative stress markers can be a good monitoring factor, and is recommended to be performed in a regular manner.